This interdisciplinary seminar course introduces One Health as an increasingly important approach to a holistic understanding of the prevention of disease and maintenance of both human and animal health. Topics include discussion of bi-directional impact of animal health on human health, the impact of earth’s changing ecology on health, issues of food and water security and preparedness, and the benefits of comparative medicine. Learning objectives:1) to describe how different disciplines contribute to the practice of One Health, 2) to discuss how interdisciplinary interventions can improve Global Health using a One Health model, and 3) to interact with One Health-relevant professionals in the Triangle and beyond. This course includes a weekly multi-campus discussion-based seminar off-site at NC Biotechnology Center. The course includes students from Duke, UNC and NCSU from diverse disciplines relevant to One Health, including: human medicine, veterinary medicine, environmental science, public health, global health, public policy, and others.