Santé Plus is a dedicated pubic health non-governmental organization in Guinea that focuses on training, capacity strengthening, and research. It works with academic partners and the Guinea One Health Coordination Office for Zoonotic Disease on One Health objectives including surveillance, preparedness and response, education and outreach. The surveillance goal is to identify opportunities for coordinating zoonotic disease surveillance across animal health, human health and environmental health sectors and to implement processes to improve sharing between sectors. Santé Plus also provides information for threat assessments to effectively prevent, detect, prepare for and respond to zoonotic disease and other One Health events with an animal health component. In 2021 Santé Plus held One Health framed webinars and local meetings and prepared publications.