In celebration of One Health Day on November 3, the U.S. Food and Drug Administration's Office of Global Policy and Strategy (OGPS) included a special One Health Section in their monthly newsletter to highlight One Health activities. Leveraging science, technology, and innovation, the FDA One Health initiative seeks to: create a multidisciplinary mindset for internal and external FDA stakeholders; provide infrastructure to sustain the effort; engage governmental partners in coordination, communication, outreach, and inclusivity; and reach globally to expand the FDA’s One Health impact.