One Health is a collaborative, multisectoral, and transdisciplinary approach—working at the local, regional, national, and global levels—with the goal of achieving optimal health outcomes recognizing the interconnection between people, animals, plants, and their shared environment. EPA’s Office of Research and Development (ORD) has been partnering with the Association of Fish and Wildlife Agencies (AFWA), the Association of State and Territorial Health Officials (ASTHO), and the Environmental Council of the States (ECOS) to raise awareness of One Health. In honor of One Health Day on November 3rd, this webinar will provide a brief overview of One Health and more information on how EPA is collaborating with our state partners to educate, inform and share best practices on One Health, including examples of EPA One Health research and how the One Health approach is being applied in Alaska and Missouri.