In an era where the boundaries between human, animal, and environmental health are increasingly blurred, the concept of One Health has never been more crucial. Zoonoses, diseases that jump from animals to humans, exemplify this interconnectedness and serve as a poignant reminder of the need for collaborative efforts across disciplines. Many articles in this collection delve into the multifaceted world of zoonotic diseases, exploring their origins, impacts, prevention strategies, and the vital role of One Health in safeguarding our planet's well-being. Please join us as we embark on a journey to better understand and address the complex challenges at the intersection of human, animal, and environmental health on this One Health Day.